Heart disease remains the world's leading cause of death, but researchers are continuing to uncover the genetic mechanisms that drive it. According to a recent Augusta University Jagwire article highlighting new research, scientists are investigating how a little-studied gene might influence the development of cardiovascular disease and whether it could become a future target for treatment.

At the center of the research is Kunzhe Dong, PhD, an investigator at Augusta University's Immunology Center of Georgia, who is examining the role of the SH3BGRL2 gene in cardiovascular cells. While the gene has previously been associated with cancer biology, early findings suggest it might also play an important role in regulating how blood vessels respond to stress and injury. Understanding that relationship could reveal new biological pathways involved in heart disease and identify novel opportunities for precision medicine.

The research aims to determine how changes in gene expression affect the function of cardiovascular cells and contribute to disease progression. By better understanding these molecular mechanisms, scientists hope to identify new therapeutic targets and improve the ability to prevent or treat cardiovascular disease before irreversible damage occurs. The work also reflects a broader shift toward precision medicine, where treatments are tailored to the underlying biology of each patient rather than relying solely on traditional risk factors.

"This gene is well known in one field, but now we're seeing it's also important in cardiovascular cells." Kunzhe Dong, PhD

To learn more about this research and connect with Kunzhe Dong, contact AU's External Communications Team mediarelations@augusta.edu to arrange an interview today.